MF-101 Bioreactor – High performance & easy operation
MF-101 Bioreactor: Utilizes highly integrated MCU control with precision PID algorithms for superior cultivation management
MF-101 Bioreactor
Precise control, curve viewing, remote operation, and high cost performance
Self-Developed Microbial Cultivation System
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Advanced Control Technology
Utilizes highly integrated MCU control with precision algorithms for superior cultivation management -
Proprietary Intelligent PID Control
Fully self-developed system incorporating Sieman’s proprietary pH/DO sensors for unmatched process control -
Smart Touch Console
Features a detachable tablet with:
✓ Microsecond response time
✓ Integrated sensor signal processing
✓ Intuitive HMI interface
✓ Wireless connectivity (Wi-Fi/Bluetooth) -
Cloud-Connected Platform
Seamless integration with Sieman Software Suite for:
• Experimental design
• Bioreactor scale-up calculations
• Fluid dynamics simulation
MF-101 Bioreactor Characteristics
- It adopts a high-performance ARM chip design to achieve more precise culture control
- Wireless portable tablet, unlimited space for free control
- Self-developed digital sensors are adopted to deeply and intelligently collaborate with the reactor
- Flexible PID intelligent control algorithm, with configurable relevant parameters
- The configuration parameters can save to the template for convenient invocation and start running with one click
- Simple and humanized human-computer interaction interface design
- Data curve can be selected with multiple parameters, and multiple batches can be compared and viewed. The data and curve can be exported
- 4 Level user management authority, supports audit trail function, complies with FDA 21 CFR Part 11
- It can be connected to a mobile phone APP to achieve remote control
- It can be interconnected to the Sieman software platform, supporting DoE, scale-up calculation, etc
- Independent and controllable, and the after-sales service response is fast
- Equipped with all the necessary components, it is ready to use right out of the box
MF-101 Bioreactor Application
- High-density fermentation of yeast
- High-density fermentation of E.coli
- High-density fermentation of Bacillus subtilis
- Microbial culture in synthetic biology
- Fungal fermentation culture
MF-101 Bioreactor Intelligent System
The MF-101 bioreactor is a complete and intelligent bioreactor system specifically optimized for microbial fermentation. This ready-to-use system comes fully equipped with all essential components and features:
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Advanced Control Architecture
High-integration, cost-effective microcontroller system enabling sophisticated control algorithms -
Seamless Workflow Integration
Detachable touch tablet bridges experimental operations with data processing -
High-Density Fermentation Specialist
Ideal for yeast, E. coli, B. subtilis, and fungal cultures -
Regulatory-Compliant Design
GMP-aligned environment with closed-loop data control
FDA 21 CFR Part 11 compliance including audit trail functionality -
Flexible Configuration
Vessel volume options (3L/5L)
Compatible with Sieman software platform for DoE and scale-up calculations -
Proprietary Sensing Technology
Self-developed DO sensors (optical/polarographic options available)
Precise, transparent measurements with independent IP
Technical Advantages
✓ 100% independent core technologies
✓ Significantly improved fermentation success rates
✓ Enhanced data processing efficiency
✓ Rapid customization services
A next-generation fermentation solution bridging R&D to production
MF-101 Bioreactor Technical Specifications Table
| Parameter | Specifications |
|---|---|
| System | Sieman MF-101 Control System |
| Tank | – Single-wall borosilicate glass – 316L stainless steel cover plate – Integrated agitator – Gas distributor – Support frame |
| Volume | 5L / 3L (selectable) |
| Ventilation | Annular bottom ventilation (30×φ1mm openings) |
| Exhaust | Condenser exhaust system |
| Sampling | Manual offline sampling port |
| pH Control | – Cascade control with acid/alkali pumps – Range: 0-14 – Accuracy: ±0.01 |
| Temperature | – PT-100 sensor – Range: 5-80°C – Accuracy: ±0.1°C – Programmable sequence control |
| DO Control | – Integrated with ventilation/stirring – Range: 0-150% – Accuracy: ±0.1% – Programmable sequence control |
| Defoaming | – Automatic liquid level detection – Pump-controlled defoamer addition |
| Tank Interface | – Modular standard interfaces – Flame-resistant inoculation port – Configurable port switching |
| Screen | Portable touch tablet controller |
| Gas Flowmeter | High-precision mass flowmeter (0-10L/min range) |
| Pump System | 4 × precision variable-speed pumps |
| Process Monitoring | – Complete parameter curve recording – Real-time data visualization |
| Data Compliance | – FDA 21 CFR Part 11 compliant – Audit trail functionality – Full data export capability |
| Control Algorithm | Adaptive PID intelligent control |
| Software Integration | – Sieman software platform connectivity – Supports DoE (Design of Experiments) – Scale-up research capabilities |
Service Commitment
We are committed to providing customers with efficient and professional after-sales service to ensure the stable operation of the equipment. The commitments are as follows:
Rapid response: Respond within 2 hours after receiving a service request and provide a solution within 48 hours (except for remote areas).
Professional technical support: On-site technical support or remote assistance is provided by Silman’s experienced after-sales engineer team.
Original factory parts guarantee: All repair and replacement parts are produced by the original factory to ensure independent compatibility and performance stability.
Lifetime service: Provide technical support throughout the entire life cycle of the equipment, including software upgrades, technical support, maintenance and care guidance, etc.
For information on the free assembly of Sieman pH sensor, please refer to the following link:
https://www.siemanbio.com/product/ab-100-online-ph-sensor/
For information on the free assembly of Sieman DO sensor, please refer to the following links:
https://www.siemanbio.com/product/optical-do-sensor/
https://www.siemanbio.com/product/polarog-polarographic-do-sensor/
The differences between the single-chip microcomputer system Bioreactor and the PLC Bioreactor can be referred to in the following article. At present, it seems that the single-chip microcomputer system Bioreactor still has more advantages in research and development, while the PLC Bioreactor has more advantages in industrial production:
https://processsolutions.com/microcontroller-vs-plc-whats-the-difference/
