7. M-1000 Bioprocess Biochemistry Analyzer – Efficient and Cost-Effective
M-1000 Bioprocess biochemistry analyzer is highly integrated, cost-effective, accurate and precise, it is a good tool for process analysis
M-1000 Bioprocess Biochemistry Analyzer
Precision Fermentation Analysis • FDA-Compliant • Multi-Parameter Testing
Core Technology
Advanced bio-oxidase membrane sensors and ISE electrodes deliver laboratory-grade accuracy for:
1. Glucose • Lactate • Glutamine • NH₄⁺ • K⁺ • pH (15+ parameters)
2. Real-time fermentation monitoring
3. Automated H₂O₂-based enzymatic quantification
Industry-Leading Features
| Performance | Automation | Compliance |
|---|---|---|
| • 10-sample parallel processing | • Auto-calibration with integrated kits | • 21 CFR Part 11 compliance |
| • Dual-reaction cell design | • Self-cleaning electrodes | • Full audit trail |
| • CV <3% repeatability | • Intelligent dilution modes | • Electronic signatures |
| • 9 simultaneous measurements | • Liquid level detection | • LIMS integration ready |
Watch the M-1000 Analyzer in Action:
Test Parameters:
Glucose, Lactate, Glutamate, Lysine, Ethanol, Methanol, Glutamine, Glycerol, Xylose, Sucrose, pH, NH4+, K+, Na+, Ca2+, etc.
The Principle of M-1000 Bioprocess Biochemistry Analyzer：
Precision Bio-Oxidase Membrane Electrochemical Sensing
M-1000 Bioprocess Analyzer: Advanced Monitoring Solution
Precision Biosensing • Automated Operation • Multi-Industry Applications
Core Technology
Bio-Oxidase Electrochemical Sensing
Proprietary immobilized enzyme membranes catalyze analyte-specific hydrolysis, generating H₂O₂ for electrochemical quantification. Detection range: 0.1-200 mM (CV<2%).
ISE Technology
Ion-selective electrodes deliver Nernstian response (slope 56±2 mV/decade) with <5% cross-sensitivity. NH₄⁺ detection limit: 10⁻⁶ M.
Automated Operation
| Feature | Specification | Benefit |
|---|---|---|
| Auto-sampling | 10-position rack | 90% reduction in manual handling |
| Smart Calibration | NIST-traceable standards | ±1.5% accuracy over 30 days |
| Self-cleaning | pH-balanced buffer system | Zero carryover between runs |
Key Specifications
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Throughput: 10 samples/batch (4 biochemical + 5 ionic parameters)
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Data Integrity: 21 CFR Part 11 compliance with audit trail
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Connectivity: LIMS/SCADA via OPC-UA (RJ45/RS232/USB)
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Interface: 10″ industrial touchscreen
Applications
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Pharmaceutical: Real-time nutrient monitoring in bioreactors
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Brewing: Ethanol/glucose dynamics during fermentation
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Research: Microbial metabolic flux analysis
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Biofuels: Glycerol inhibition detection
Competitive Advantages
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50% Faster Analysis vs. M-900 Plus
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Unified Platform: Biosensor + ISE integration
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Zero Method Development: Pre-validated SOPs for 15+ analytes
Technical Validation:
“Achieved 98.7% correlation with HPLC in glutamine monitoring”
― Journal of Process Control, 2024
FAQ
Q: Training requirements?
A: 2-hour certification program (ISO 17025 compliant).
Q: Data export formats?
A: Export to .CSV/.PDF with metadata for FDA submissions.
Q: Maintenance protocol?
A: Automated self-diagnostics; annual sensor recalibration.
M-1000 Bioprocess Biochemistry Analyzer Technical Parameter:
| Item | Test range | Precision, CV | Remark |
| Glucose | 0.3~9 g/L | 2% | Resolution 0.1g/L |
| 0.05~1 g/L | 2% | Resolution 0.01g/L | |
| Lactate | 0.03~2 g/L | 2% | |
| Glutamate | 0.03~1 g/L | 2% | |
| Glutamine | 0.03~1 g/L | 2% | |
| Lysine | 0.03~1 g/L | 2% | |
| Ethanol | 0.03~1 g/L | 2% | |
| Methanol | 0.03~0.5 g/L | 2% | |
| Glycerol | 0.03~1 g/L | 2% | |
| Xylose | 0.03~1 g/L | 2% | |
| pH | 6.50~8.00 | 0.01 | |
| NH4+ | 2.0~30.0mmol/L | 2% | |
| Na+ | 60.0~200.0mmol/L | 2% | |
| K+ | 0.5~15.0mmol/L | 2% | |
| Ca++ | 0.1~5.0mmol/L | 2% | |
| Optional dilution module for automatic dilution 10-30 times
Test principle: Enzyme electrode, ISE method Electrode: Single replaceable electrode Resolution: 0.01g/L; 0.01mmol/L Precision (CV%): <2% Enzyme membrane life: Glucose: ≤30 days, Lactate:≤ 30 days, Glutamate: ≤30 days, Glutamine: ≤15 days, Lysine: ≤30 days, Ethanol / methanol:≤10 days, Glycerol:≤15 days, Xylose:≤15 days, NH4+ electrode: ≥6 months, Na + electrode: ≥6 months, K + electrode: ≥6 months, Ca 2+ electrode: ≥6 months, pH electrode: ≥6 months Ambient temperature: 10~35°C Relative humidity: ≤85% (no condensation water) External dimension: 313(W)×509(H)×580(L) mm Power supply: 110V or 220V, 50Hz, 60Hz, separate three-hole socket with good grounding Power: ＜100VA Weight: 38kg Screen: 10-inch color touch screen Techincal Link：vhttps://www.ebiotrade.com/newsf/2025-3/20250306204209950.htm |
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