AMF-101N Integrated Online Bioreactor – Precise detection, stable control

AMF-101N Integrated Online Bioreactor

The AMF-101N Integrated Online Bioreactor features a removable touchscreen panel and a highly integrated control system, incorporating sterile microfluidic channels. It enables real-time monitoring and dynamic regulation of biochemical parameters, OD values, and other critical metrics, supporting complex metabolic control processes.

The Era of Affordable, Integrated Online Bioreactors Has Arrived

Smart Metabolic Control | Precision Fermentation
Core Proprietary Technologies | Real-time Biochemical & Ions Analysis | Real-time OD Monitoring | Closed-loop Process Control

AMF-101N Integrated Online Bioreactor Key Features

• Integrated sterile auto-sampling flow path enables online biochemical & ion detection and intelligent closed-loop control

• Novel optical technology for online OD monitoring, dynamic feeding strategy adjustment, and precise induction

• High-performance ARM chip design for refined cultivation control

• Wireless movable tablet for unrestricted remote operation

• Proprietary digital sensors with deep intelligent reactor coordination

• Flexible PID control algorithm with configurable parameters

• Save parameter templates for one-click operation in subsequent runs

• Multi-parameter batch comparison with exportable data/curves

• Four-tier user management with audit trail (FDA 21 CFR Part 11 compliant)

• Mobile APP connectivity for remote control

• Compatible with Silverman Software Platform (experimental design, scale-up calculations)

• Domestic supply chain ensures rapid after-sales support

• Fully equipped for plug-and-play operation

• Support tank pressure control

• Optional exhaust gas analysis module

   

AMF-101N Integrated Online Bioreactor Application Cases

1. Yeast High-Density Fermentation

   • Real-time glycerol monitoring (for Pichia pastoris induction)

   • Precise methanol feeding to avoid toxicity accumulation

2. E. coli High-Density Fermentation

   • Real-time OD/glucose monitoring

   • Automatic specific growth rate calculation for optimized feeding/induction

3. Synthetic Biology

   • Multi-parameter co-analysis for high-yield strain screening

   • Reliable small-scale process development

4. PHA (Biodegradable Plastic) Production

   • Glucose feedback optimizes carbon flux allocation

   • PHA yield increased from 30% to 45% with PDI <1.3

5. Beer Continuous Fermentation

   • Ethanol/glycerol monitoring reduces fermentation variability (±5% → ±1%)

   • 40% improvement in flavor stability via maltose closed-loop control

AMF-101N vs. Traditional Bioreactors: A Paradigm Shift in Bioprocessing

The AMF-101 represents a breakthrough in real-time analytical control, data-driven optimization, process stability, and end-to-end efficiency—particularly tailored for high-value biopharmaceutical production (e.g., antibiotics, monoclonal antibodies, vaccines) and complex metabolic engineering research.

Key Advantages
▸ Configurable Scalability

• Available in 3L/5L/7L/10L working volumes

• Modular design allows customized add-on/reduction of components

• Supports up to 13 real-time monitoring parameters with closed-loop feedback for precision cultivation

▸ Regulatory-Compliant Intelligence

• Fully aligns with current GMP requirements

• Implements closed-loop data control for dynamic parameter adjustment and feeding strategy optimization

• Ensures data integrity (FDA 21 CFR Part 11 compliant) with full audit trail capability

▸ Technological Leap

• Transforms bioreactors from mere “production vessels” into intelligent metabolic control systems

• Achieves generational advancements in biomanufacturing accuracy, efficiency, and autonomy through deep integration of proprietary technologies

AMF-101N Integrated Online Bioreactor Specifications

* Optional exhaust gas analysis module is available for real-time online viewing of the values of O2, CO2, OUR, CER and RQ