M-1000 Bioprocess Biochemistry Analyzer

M-1000 Bioprocess biochemistry analyzer is highly integrated, cost-effective, accurate and precise, it is a good tool for process analysis

M-1000 Bioprocess Biochemistry Analyzer

Precision Fermentation Analysis • Comply with the relevant GMP regulations • Multi-Parameter Testing

Core Technology
Advanced bio-oxidase membrane sensors and ISE electrodes deliver laboratory-grade accuracy for:
1. Glucose • Lactate • Glutamine • NH₄⁺ • K⁺ • pH (15+ parameters)
2. Real-time fermentation monitoring
3. Automated H₂O₂-based enzymatic quantification

Industry-Leading Features

Performance	Automation	Compliance
• 10-sample parallel processing	• Auto-calibration with integrated kits	• 21 CFR Part 11 compliance
• Dual-reaction cell design	• Self-cleaning electrodes	• Full audit trail
• CV <3% repeatability	• Intelligent dilution modes	• Electronic signatures
• 9 simultaneous measurements	• Liquid level detection	• LIMS integration ready

Watch the M-1000 Bioprocess Biochemistry Analyzer in Action:

Test Parameters:

Glucose, Lactate, Glutamate, Lysine, Ethanol, Methanol, Glutamine, Glycerol, Xylose, Sucrose, pH, NH4+, K+, Na+, Ca2+, etc.

The Principle of M-1000 Bioprocess Biochemistry Analyzer：

Precision Bio-Oxidase Membrane Electrochemical Sensing

The test substance contained in the sample will undergo an enzymatic hydrolysis reaction under the catalysis of an immobilized bio-oxidase to generate hydrogen peroxide. The concentration of the test substance is calculated by the hydrogen peroxide concentration that is generated in the testing process of hydrogen peroxide electrode.

The device will automatically calibrate standard liquids at known concentrations, and the voltage of the standard liquid is a measure of the concentration of the test substance. The unknown concentration can be obtained through the comparison with the voltage signal of the standard liquid.

M-1000 Bioprocess Biochemistry Analyzer: Advanced Monitoring Solution

Precision Biosensing • Automated Operation • Multi-Industry Applications

Core Technology

Bio-Oxidase Electrochemical Sensing
Proprietary immobilized enzyme membranes catalyze analyte-specific hydrolysis, generating H₂O₂ for electrochemical quantification. Detection range: 0.1-200 mM (CV<2%).

ISE Technology
Ion-selective electrodes deliver Nernstian response (slope 56±2 mV/decade) with <5% cross-sensitivity. NH₄⁺ detection limit: 10⁻⁶ M.

Automated Operation

Feature	Specification	Benefit
Auto-sampling	10-position rack	90% reduction in manual handling
Smart Calibration	NIST-traceable standards	±1.5% accuracy over 30 days
Self-cleaning	pH-balanced buffer system	Zero carryover between runs

Key Specifications

Throughput: 10 samples/batch (4 biochemical + 5 ionic parameters)
Data Integrity: 21 CFR Part 11 compliance with audit trail
Connectivity: LIMS/SCADA via OPC-UA (RJ45/RS232/USB)
Interface: 10″ industrial touchscreen

Applications

Pharmaceutical: Real-time nutrient monitoring in bioreactors
Brewing: Ethanol/glucose dynamics during fermentation
Research: Microbial metabolic flux analysis
Biofuels: Glycerol inhibition detection

Competitive Advantages

50% more convenience vs. M-900 Plus
Unified Platform: Biosensor + ISE integration
Zero Method Development: Pre-validated SOPs for 15+ analytes

Technical Validation:

“Achieved 98.7% correlation with HPLC in glutamine monitoring”
― Journal of Process Control, 2024

FAQ

Q: Training requirements?
A: 2-hour certification program (ISO 17025 compliant).

Q: Data export formats?
A: Export to .CSV/.PDF with metadata for FDA submissions.

Q: Maintenance protocol?
A: Automated self-diagnostics; annual sensor recalibration.

M-1000 Bioprocess Biochemistry Analyzer Technical Parameter:

Item	Test range	Precision, CV	Remark
Glucose	0.3~9 g/L	2%	Resolution 0.1g/L
Glucose	0.05~1 g/L	2%	Resolution 0.01g/L
Lactate	0.03~2 g/L	2%
Glutamate	0.03~1 g/L	2%
Glutamine	0.03~1 g/L	2%
Lysine	0.03~1 g/L	2%
Ethanol	0.03~1 g/L	2%
Methanol	0.03~0.5 g/L	2%
Glycerol	0.03~1 g/L	2%
Xylose	0.03~1 g/L	2%

pH	6.50~8.00	0.01
NH4+	2.0~30.0mmol/L	2%
Na+	60.0~200.0mmol/L	2%
K+	0.5~15.0mmol/L	2%
Ca++	0.1~5.0mmol/L	2%
Optional dilution module for automatic dilution 10-30 times Test principle: Enzyme electrode, ISE method Electrode: Single replaceable electrode Resolution: 0.01g/L; 0.01mmol/L Precision (CV%): <2% Enzyme membrane life: Glucose: ≤30 days, Lactate:≤ 30 days, Glutamate: ≤30 days, Glutamine: ≤15 days, Lysine: ≤30 days, Ethanol / methanol:≤10 days, Glycerol:≤15 days, Xylose:≤15 days, NH4+ electrode: ≥6 months, Na + electrode: ≥6 months, K + electrode: ≥6 months, Ca 2+ electrode: ≥6 months, pH electrode: ≥6 months Ambient temperature: 10~35°C Relative humidity: ≤85% (no condensation water) External dimension: 313(W)×509(H)×580(L) mm Power supply: 110V or 220V, 50Hz, 60Hz, separate three-hole socket with good grounding Power: ＜100VA Weight: 38kg Screen: 10-inch color touch screen Techincal Link：vhttps://www.ebiotrade.com/newsf/2025-3/20250306204209950.htm