MF-101 Bioreactor
MF-101 Bioreactor: Utilizes highly integrated MCU control with precision algorithms for superior cultivation management
MF-101 Bioreactor
Self-Developed Microbial Cultivation System
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Advanced Control Technology
Utilizes highly integrated MCU control with precision algorithms for superior cultivation management -
Proprietary Intelligent PID Control
Fully self-developed system incorporating Sieman’s proprietary pH/DO sensors for unmatched process control -
Smart Touch Console
Features a detachable tablet with:
✓ Microsecond response time
✓ Integrated sensor signal processing
✓ Intuitive HMI interface
✓ Wireless connectivity (Wi-Fi/Bluetooth) -
Cloud-Connected Platform
Seamless integration with Sieman Software Suite for:
• Experimental design
• Bioreactor scale-up calculations
• Fluid dynamics simulation
MF-101 Bioreactor Characteristics
- It adopts a high-performance ARM chip design to achieve more precise culture control
- Wireless portable tablet, unlimited space for free control
- Self-developed digital sensors are adopted to deeply and intelligently collaborate with the reactor
- Flexible PID intelligent control algorithm, with configurable relevant parameters
- The configuration parameters can save to the template for convenient invocation and start running with one click
- Simple and humanized human-computer interaction interface design
- Data curve can be selected with multiple parameters, and multiple batches can be compared and viewed. The data and curve can be exported
- 4 Level user management authority, supports audit trail function, complies with FDA 21 CFR Part 11
- It can be connected to a mobile phone APP to achieve remote control
- It can be interconnected to the Sieman software platform, supporting DoE, scale-up calculation, etc
- Independent and controllable, and the after-sales service response is fast
- Equipped with all the necessary components, it is ready to use right out of the box
MF-101 Bioreactor Application
- High-density fermentation of yeast
- High-density fermentation of E.coli
- High-density fermentation of Bacillus subtilis
- Microbial culture in synthetic biology
- Fungal fermentation culture
MF-101 Bioreactor Intelligent System
The MF-101 bioreactor is a complete and intelligent bioreactor system specifically optimized for microbial fermentation. This ready-to-use system comes fully equipped with all essential components and features:
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Advanced Control Architecture
High-integration, cost-effective microcontroller system enabling sophisticated control algorithms -
Seamless Workflow Integration
Detachable touch tablet bridges experimental operations with data processing -
High-Density Fermentation Specialist
Ideal for yeast, E. coli, B. subtilis, and fungal cultures -
Regulatory-Compliant Design
GMP-aligned environment with closed-loop data control
FDA 21 CFR Part 11 compliance including audit trail functionality -
Flexible Configuration
Vessel volume options (3L/5L)
Compatible with Sieman software platform for DoE and scale-up calculations -
Proprietary Sensing Technology
Self-developed DO sensors (optical/polarographic options available)
Precise, transparent measurements with independent IP
Technical Advantages
✓ 100% independent core technologies
✓ Significantly improved fermentation success rates
✓ Enhanced data processing efficiency
✓ Rapid customization services
A next-generation fermentation solution bridging R&D to production
MF-101 Bioreactor Technical Specifications Table
| Parameter | Specifications |
|---|---|
| System | Sieman MF-101 Control System |
| Tank | – Single-wall borosilicate glass – 316L stainless steel cover plate – Integrated agitator – Gas distributor – Support frame |
| Volume | 5L / 3L (selectable) |
| Ventilation | Annular bottom ventilation (30×φ1mm openings) |
| Exhaust | Condenser exhaust system |
| Sampling | Manual offline sampling port |
| pH Control | – Cascade control with acid/alkali pumps – Range: 0-14 – Accuracy: ±0.01 |
| Temperature | – PT-100 sensor – Range: 5-80°C – Accuracy: ±0.1°C – Programmable sequence control |
| DO Control | – Integrated with ventilation/stirring – Range: 0-150% – Accuracy: ±0.1% – Programmable sequence control |
| Defoaming | – Automatic liquid level detection – Pump-controlled defoamer addition |
| Tank Interface | – Modular standard interfaces – Flame-resistant inoculation port – Configurable port switching |
| Screen | Portable touch tablet controller |
| Gas Flowmeter | High-precision mass flowmeter (0-10L/min range) |
| Pump System | 4 × precision variable-speed pumps |
| Process Monitoring | – Complete parameter curve recording – Real-time data visualization |
| Data Compliance | – FDA 21 CFR Part 11 compliant – Audit trail functionality – Full data export capability |
| Control Algorithm | Adaptive PID intelligent control |
| Software Integration | – Sieman software platform connectivity – Supports DoE (Design of Experiments) – Scale-up research capabilities |
Service Commitment
We are committed to providing customers with efficient and professional after-sales service to ensure the stable operation of the equipment. The commitments are as follows:
Rapid response: Respond within 2 hours after receiving a service request and provide a solution within 48 hours (except for remote areas).
Professional technical support: On-site technical support or remote assistance is provided by Silman’s experienced after-sales engineer team.
Original factory parts guarantee: All repair and replacement parts are produced by the original factory to ensure independent compatibility and performance stability.
Lifetime service: Provide technical support throughout the entire life cycle of the equipment, including software upgrades, technical support, maintenance and care guidance, etc.
