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M-900 Plus Automated biochemistry analyzer

M-900 Plus automated analyzer is very suitable for cell culture process development. Cost is low, fast speed, optional pre-dilution function.


Contact Form Demo (#3)

Test biochemical and ionic parameters, more comprehensive, accurate & fast


Test menu: Glucose, Sucrose, Lactate, Glutamine, Glutamate, Lysine, Ethanol, Methanol, Glycerol, Xylose, pH, NH4+, K+, Na+, Ca2+, Osm, etc.

*Can be converted into English version, optional dilution function.

Here is a video of the sample testing process:
As a manufacturer, Sieman has launched a new generation instrument—M-900 plus Automated Bioprocess Biochemistry Analyzer.
M-900 plus is very suitable for cell culture process development.
The accuracy and precision are proven to be reliable and the cost is low, fast speed, just 20s for a single item. All parameters are tested within 2min. Refer to the following link:




M-900 plus uses immobilized enzyme membrane biosensor and ion selective electrode to detect the concentration of the sample to be measured.An oxidase corresponding to the test substrate is fixed in the enzyme membrane, and the substrate is catalyzed to produce hydrogen peroxide. The hydrogen peroxide is measured by a hydrogen peroxide electrode, and the concentration of the test substrate is calculated from the hydrogen peroxide concentration.

Ion-selective electrode(ISE) is a type of electrochemical sensor that can convert the changes in the activity of the ions in the solution into changes in the electrode potential, and the logarithm of the ion activity in the solution has a linear relationship with the electrode potential. “Ion-selective electrode” means that the sensor is only sensitive to specific ions. For example, the ammonium electrode is only sensitive to ammonium ions in the solution, but not sensitive to potassium and other ions.

M-900 plus automatically collects samples and imports them into the test area. The test substance contained in the sample generates an electrical signal on a specific electrode. The instrument calculates the concentration of the test object by collecting the electrical signals on the electrodes.Before the test, the instrument calibrates the standard with a known concentration.and the voltage value of the standard item is a measure of the concentration of the test substance. The unknown concentration can be obtained through the comparison with the voltage signal of the standard item. The sensor electrodes will be automatically cleaned by the system buffer solution after each measurement is completed, and the next test can be performed after cleaning.


M-900 plus Automated Bioprocess Biochemistry Analyzer Features
  • Fully automatic dilution, even mixing and cleaning system
  • High-precision Teflon coating sampling needle
  • Imported pump and valve control system with ultra-high reliability
  • Fully automatic dilution and sampling to avoid personal error
  • Fully automatic calibration to ensure the accuracy of test results
  • Trace samples, samples to be tested at any time
  • Reliable performance and quality due to independent core technologies based on more than 20 years of manufacturing experience
  • Excellent electromagnetic compatibility performance to ensure the reliability of the device system
  • Built-in sample tray with up to 15 sample positions, supporting test tubes and micro cups
  • Visual and intuitive operation interface, 10-inch color touch screen human-computer interaction
  • Test results being reviewed, printed and transmitted in real time
  • External reagent in low cost and easy operation

M-900 Plus Automated Bioprocess Biochemistry Analyzer 01

Correlation between M-900 and HPLC results

Accuracy of Glucose concentration in cell medium

Number of samples The average number test results  mg/dl SD % CV
50 68 1.36 2
50 189.6 3.41 1.8
50 265.7 5.05 1.9
50 351.2 5.27 1.5
50 501.8 10.04 2
50 619.6 12.39 2


M-900 plus Automated Bioprocess Biochemistry Analyzer Specifications
Test principle Enzyme electrode method
Electrode Single replaceable electrode
Measuring range Glucose(Article number: C1001): 0.3~9 g/L

Glucose(Article number: G1001): 0.05~1 g/L 

Glutamine: 0.03~1 g/L

Glycerin: 0.03~1 g/L

Xylose: 0.03~1 g/L

Lactate: 0.03~2 g/L

Glutamate: 0.03~1 g/L

Lysine: 0.03~1 g/L

Methanol: 0.03~0.5 g/L

Ethanol: .0.03~1 g/L

The machine with pre-dilution function can expand the above test range by 10 to 30 times.

NH4+2~30mmol/L,  Na+60~200mmol/L,

K+: 0.5~15mmol/L, Ca2+0.1~5mmol/L, pH: 6~8

Resolution 0.01g/L; 0.01mmol/L
Precision (CV%) <2%
Enzyme membrane life Glucose: ≤30 days, Lactate:≤30days, Glutamate: ≤30 days,

Lysine: ≤30 days, Ethanol / methanol: 10 days,

Glutamine: ≤15days, Glycerin: 15 days, Xylose15 days,

NH4+ electrode: ≥4 months, Na+ electrode: ≥6 months,

K+ electrode: ≥6 months, Ca2+ electrode: ≥6 months,

pH electrode: ≥4 months

Ambient temperature 10~35°C
Relative humidity ≤85% (no condensation water)
External dimension 660×530×520 mm
Power supply 110V or 220V, 50Hz, 60Hz, separate three-hole socket with good grounding
Power 100VA
Weight 35kg
Screen 10-inch color touch screen

*Automatic injection and detection, automatic dilution is optional

M-900 Plus Automated Bioprocess Biochemistry Analyzer 02


Contact Form Demo (#3)